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一般說明
MCB-613 (4-Ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone) belongs to the chalcone class of compounds. It is an anti-neoplastic compound.
應用
MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.
生化／生理作用
MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.
MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Lei Wang et al.
Cancer cell, 28(2), 240-252 (2015-08-13)
By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics. High-throughput screening for SRC small molecule inhibitors (SMIs) uncovered MCB-613 as a potent SRC small molecule "stimulator" (SMS).
Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death
Hossain MM, et al.
Testing, 9(14), 11707-11707 (2018)
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