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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
light yellow to yellow-green
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
2-8°C
SMILES 字串
NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21
InChI
1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
InChI 密鑰
LCYAYKSMOVLVRL-UHFFFAOYSA-N
生化／生理作用
SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing stem cells to proliferate. 15-PGDH degrades prostaglandin PGE2 and is a negative regulator of tissue regeneration and repair. SW033291 inhibition of 15-PGDH doubled levels of PGE2 and doubled rates of colon and liver tissue regeneration. Mice given SW033291 after receiving a bone marrow transplant had a two- to threefold increase in the number of donor cells that homed to the their bone marrow.
訊號詞
Warning
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yichao Zhang et al.
iScience, 24(9), 102983-102983 (2021-09-07)
Rosiglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligand, has been reported to reduce growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in 10 patients with acromegaly. However, the mechanisms remain unknown. Here, we reveal that PPARγ directly enhances 15-hydroxyprostaglandin
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