推荐产品
品質等級
化驗
≥99%
形狀
solid
溶解度
H2O: soluble
alcohol: soluble
起源
Schering Plough
SMILES 字串
Cl.Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C
InChI
1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H
InChI 密鑰
BEEDODBODQVSIM-UHFFFAOYSA-N
基因資訊
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352)
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生化／生理作用
盐酸羟甲唑啉是一种部分 α2A-肾上腺素受体激动剂；5-HT1A、5-HT1B 和 5-HT1D 血清素受体的激动剂。它是 5-HT1C 血清素受体的混合激动剂-拮抗剂。
特點和優勢
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Danger
危險分類
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Aquatic Chronic 3 - Eye Dam. 1
儲存類別代碼
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
其他客户在看
P Schoeffter et al.
European journal of pharmacology, 196(2), 213-216 (1991-04-17)
Oxymetazoline was recognized with nanomolar affinity by 5-HT1A, 5-HT1B and 5-HT1D binding sites and mimicked the effects of 5-hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests. At 5-HT1C receptors, oxymetazoline
H Law et al.
Journal of medicinal chemistry, 41(13), 2243-2251 (1998-06-19)
Benzylimidazolines may represent a class of 5-HT1D ligands that has yet to be exploited. On the basis of a previous report that the 2-(substituted-benzyl)imidazoline alpha-adrenergic agonist oxymetazoline (8) binds with high affinity at calf brain 5-HT1D receptors, we explored the
Vittorio Canale et al.
Molecules (Basel, Switzerland), 26(13) (2021-07-03)
The complex pathophysiology of depression, together with the limits of currently available antidepressants, has resulted in the continuous quest for alternative therapeutic strategies. Numerous findings suggest that pharmacological blockade of α2-adrenoceptor might be beneficial for the treatment of depressive symptoms
K Horie et al.
British journal of pharmacology, 116(1), 1611-1618 (1995-09-01)
1. To investigate the structure-activity relationships of alpha-adrenoceptor agonists for the alpha 1-adrenoceptor subtypes, we have compared the imidazoline class of compounds, oxymetazoline and cirazoline, with the phenethylamine, noradrenaline, in their affinities and also in their intrinsic activities in Chinese
Sylwia K Paszun et al.
Acta poloniae pharmaceutica, 70(6), 1079-1085 (2014-01-05)
The presented study aimed at the evaluation of hydrochlorothiazide influence on cilazapril stability in model mixture and fixed dose tablet formulation. The degradation of cilazapril in the presence of hydrochlorothiazide took place according to autocatalytic reaction kinetic mechanism, described mathematically
商品
α2-Adrenoceptors
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