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品質等級
化驗
≥98% (HPLC)
形狀
powder (flocculent)
顏色
white to beige
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3
InChI
1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)
InChI 密鑰
ZATJMMZPGVDUOM-UHFFFAOYSA-N
生化／生理作用
FDI-6是FOXM1的一种有效且特异性抑制剂，其可可阻止DNA的结合。FDI-6可与FOXM1蛋白结合，并特异性下调FOXM1激活的基因。
叉头结构域抑制剂6（FDI-6）可用于治疗因血液生成减少而导致贫血的患者。在Hep-2细胞中，FDI-6可以刺激细胞死亡，还有助于防止细胞增殖、侵袭和迁移。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1
Liu Y, et al.
Chinese Journal of Catalysis, 33(5), 611-616 (2017)
Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors
Youn M, et al.
Haematologica, 102(5), 826-834 (2017)
Andrew P Sawaya et al.
Nature communications, 11(1), 4678-4678 (2020-09-18)
Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb amputations and a shortened lifespan. However, molecular mechanisms contributing to the pathogenesis of DFUs remain poorly understood. We use next-generation sequencing to generate a human dataset
Sarah Franco et al.
Heliyon, 6(6), e04028-e04028 (2020-06-25)
Accelerated smooth muscle cell (SMC) proliferation is the primary cause of intimal hyperplasia (IH) following vascular interventions. Forkhead Box M1 (FOXM1) is considered a proliferation-associated transcription factor. However, the presence and role of FOXM1 in IH following vascular injury have
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