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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to light brown
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
InChI
1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
InChI 密鑰
DMIDPTCQPIJYFE-UHFFFAOYSA-N
生化／生理作用
SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC50 value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC50 value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website.
XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
特點和優勢
SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
其他說明
SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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