跳转至内容
Merck

SML1075

Sigma-Aldrich

Atglistatin 抑制剂

≥98% (HPLC), powder, adipose triglyceride lipase inhibitor

别名:

3-(4'-(二甲氨基)-[1,1'-联苯] -3-基)-1,1-二甲基脲

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C17H21N3O
分子量:
283.37
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

Atglistatin 抑制剂, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O

InChI

1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)

InChI 密鑰

AWOPBSAJHCUSAS-UHFFFAOYSA-N

應用

阿格列汀是一种选择性助理甘油三酯胺酶抑制剂。

生化/生理作用

Atglistatin 是第一个选择性抑制脂肪甘油三酯脂肪酶 (ATGL) 的药物,ATGL 是参与从细胞甘油三酯储存库动员脂肪酸的限速酶。在大肠埃希菌中,Atglistatin 的IC50为0.7μM,对单甘油脂肪酶(MGL)、激素敏感性脂肪酶(HSL)或胰脂肪酶和脂蛋白脂肪酶PNPLA6和PNPLA7无活性。ATGL从细胞甘油三酸酯储存物中生成二酰基甘油,然后被激素敏感性脂肪酶(HSL)和甘油单酸酯脂肪酶降解为甘油和脂肪酸,从而促进了与胰岛素抵抗发展有关的脂毒性代谢产物的合成。 研究表明,Atglistatin抑制ATGL可减少“体外”“体内”的脂肪酸动员

其他說明

产品由格拉茨大学/格拉茨技术大学授权生产。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
Hong S, et al.
Molecular Metabolism (2018)
Hongyi Zhou et al.
JCI insight, 5 (2019-06-12)
Mutations in BSCL2 gene underlie human type 2 Berardinelli-Seip Congenital Lipodystrophy (BSCL2) disease. Global Bscl2-/- mice recapitulate human BSCL2 lipodystrophy and develop insulin resistance and hypertrophic cardiomyopathy. The pathological mechanisms underlying the development of lipodystrophy and cardiomyopathy in BSCL2 are
Xirui Liu et al.
Molecular cancer, 17(1), 90-90 (2018-05-17)
Abnormal metabolism, including abnormal lipid metabolism, is a hallmark of cancer cells. Some studies have demonstrated that the lipogenic pathway might promote the development of hepatocellular carcinoma (HCC). However, the role of the lipolytic pathway in HCC has not been
Lena Pernas et al.
Cell metabolism, 27(4), 886-897 (2018-04-05)
How intracellular pathogens acquire essential non-diffusible host metabolites and whether the host cell counteracts the siphoning of these nutrients by its invaders are open questions. Here we show that host mitochondria fuse during infection by the intracellular parasite Toxoplasma gondii
Kasparas Petkevicius et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(2), e21266-e21266 (2021-01-24)
Tissue-resident macrophages are required for homeostasis, but also contribute to tissue dysfunction in pathophysiological states. The sympathetic neurotransmitter norepinephrine (NE) induces an anti-inflammatory and tissue-reparative phenotype in macrophages. As NE has a well-established role in promoting triglyceride lipolysis in adipocytes

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门