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Merck
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主要文件

O1012

Sigma-Aldrich

油酰辅酶 A 锂盐

≥90% (HPLC)

别名:

顺式 -9-十八烯酰辅酶A

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About This Item

经验公式(希尔记法):
C39H68N7O17P3S
分子量:
1031.98
分類程式碼代碼:
41106305
NACRES:
NA.51

品質等級

化驗

≥90% (HPLC)

形狀

powder

溶解度

H2O: soluble-50 mg/mL, clear, colorless

儲存溫度

−20°C

應用

辅酶 A 作为酰基载体,乙酰辅酶 A 发挥作用。油酰辅酶 A 可能用于研究酰基辅酶 A:胆固醇酰基转移酶 1 (ACAT1) 等酶参与长链脂肪酸胆固醇酯化的特异性和动力学。

生化/生理作用

油酰辅酶A是一种重要的底物,对于1-烷基-2,3-二酰甘油(ADG)和哈德氏腺(HG)1-烷基-2,3-二酰甘油的超长链单不饱和脂肪酸的生物合成至关重要。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ta-Yuan Chang et al.
American journal of physiology. Endocrinology and metabolism, 297(1), E1-E9 (2009-01-15)
The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs.
Leon C, Hill JS, Wasan KM.
Pharmaceut. Res., 22, 1578-1588 (2005)
Mariana Igoillo-Esteve et al.
International journal for parasitology, 41(3-4), 429-438 (2010-12-18)
Metabolism in trypanosomatids is compartmentalised with major pathways, notably glycolysis, present in peroxisome-like organelles called glycosomes. To date, little information is available about the transport of metabolites through the glycosomal membrane. Previously, three ATP-binding cassette (ABC) transporters, called GAT1-3 for
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2, 3-diacylglycerol
Miyazaki M, et al.
The Journal of Biological Chemistry, 276(42), 39455-39461 (2001)
Catherine C Y Chang et al.
Biochemistry, 49(46), 9957-9963 (2010-10-23)
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane-bound enzyme utilizing long-chain fatty acyl-coenzyme A and cholesterol to form cholesteryl esters and coenzyme A. Previously, we had expressed tagged human ACAT1 (hACAT1) in CHO cells and purified it to homogeneity; however

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