推荐产品
product name
马兜铃酸I, powder
化驗
≥90% (HPLC)
形狀
powder
顏色
yellow
mp
269-270 °C
溶解度
DMSO: soluble
ethanol: soluble
儲存溫度
2-8°C
SMILES 字串
COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O
InChI
1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)
InChI 密鑰
BBFQZRXNYIEMAW-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
一般說明
马兜铃酸是一种天然植物代谢物，存在于马兜铃属、Bragantia属或细辛属植物中。它包括硝基菲羧酸（如马兜铃酸I和II）的混合物。
應用
马兜铃酸I 已用于：
- 作为标准品，通过高效液相色谱法分析云杉马兜铃粗提物
- 研究对组蛋白去乙酰化酶3（HDAC3）畸变和肾纤维化的影响
- 诱导急性马兜铃酸肾病，研究对小鼠miRNA和mRNA表达的影响
生化／生理作用
马兜铃酸是蛇毒中磷脂酶A2（PLA2）、透明质酸酶和乙酰胆碱酯酶血浆蛋白酶的有效抑制剂。马兜铃酸被认为是一种草药，对产科、蛇咬伤、痛风和风湿病有治疗作用。它具有抗炎和抗疟疾的特性。此外，它还被认为是一种基因毒性诱变原，可引起马兜铃酸肾病（AAN），特征为间质纤维化和尿路上皮癌。
有效的磷脂酶A2 抑制剂，包括钙离子载体诱导的嗜中性粒细胞磷脂酶A2 活性。实验动物模型的肾肿瘤引发剂。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Carc. 1A - Muta. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
Chung-Hsin Chen et al.
International journal of cancer, 133(1), 14-20 (2013-01-08)
Aristolochic acid (AA), a component of all Aristolochia-based herbal medicines, is a potent nephrotoxin and human carcinogen associated with upper urinary tract urothelial carcinoma (UUC). To investigate the clinical and pathological characteristics of AA-induced UUC, this study included 152 UUC
Guang-Xing Shui et al.
Evidence-based complementary and alternative medicine : eCAM, 2017, 9536458-9536458 (2017-04-20)
Objectives. The effects of the traditional formula Dahuang Fuzi Decoction (DFD) on chronic aristolochic acid nephropathy (AAN) in mice and its underlying mechanisms were studied. Methods. Mice were randomly divided into the following six groups: the control group, the model
Xiao Y Dai et al.
Oncotarget, 7(10), 10841-10856 (2016-02-26)
Aristolochic acid nephropathy (AAN) is a progressive kidney disease caused by some Chinese herbal medicines, but treatment remains ineffective. Macrophage accumulation is an early feature in human and experimental AAN; however, the role of macrophages in chronic AAN is unknown.
Hong Lu et al.
Mediators of inflammation, 2016, 2174682-2174682 (2016-06-18)
Background. Macrophage migration inhibitory factor (MIF) is an important immunoregulatory cytokine involved in inflammation, which may be one important reason resulting in matrix deposition in renal tissues after injury. However, the underlying mechanisms have not yet been elucidated. Methods and
Jie Wei et al.
Journal of chromatography. A, 1246, 129-136 (2012-04-10)
A novel silica-based reversed-phase/strong anion-exchange mixed-mode stationary phase named C18SAX was synthesized based on the polar-copolymerized approach. C18SAX stationary phase showed excellent compatibility with 100% aqueous mobile phase and comparable performance with commercial SunFire™ C18 column in terms of column
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门