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化驗
≥95% (HPLC)
形狀
powder
顏色
white to off-white
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CCl
InChI
1S/C24H33ClN4O8/c1-12(2)21(24(37)26-13(3)22(35)28-17(10-20(33)34)19(32)11-25)29-23(36)18(27-14(4)30)9-15-5-7-16(31)8-6-15/h5-8,12-13,17-18,21,31H,9-11H2,1-4H3,(H,26,37)(H,27,30)(H,28,35)(H,29,36)(H,33,34)/t13-,17-,18-,21-/m0/s1
InChI 密鑰
UOUBHJRCKHLGFB-DGJUNBOTSA-N
Amino Acid Sequence
Ac-Tyr-Val-Ala-Asp-Chloromethylketone
應用
Ac-YVAD-cmk用作：
- 用作炎症体抑制剂，在刺激前加入THP-1细胞或PBMC（外周血单个核细胞）
- 用作caspase-1抑制剂，注射进C57BL / 6小鼠体内
- 用作caspase-1抑制剂，在造血干细胞移植（HSCT）前和移植期间给药小鼠，评估其对骨髓炎性损伤的影响
- 消除富含组氨酸蛋白II (HRPII)对内皮细胞跨膜电阻（TEER）的影响
- 用作caspase-1抑制剂，治疗MCF-7肿瘤异种移植小鼠，验证体内条件下，炎症体激活在肿瘤生长中的作用
生化／生理作用
Ac-YVAD-cmk是半胱氨酸蛋白酶-1（白细胞介素-1β 转化酶，ICE）的不可以抑制剂，具有抗半胱氨酸蛋白酶-4活性。Ac-YVAD-cmk具有抗凋亡，抗炎症和神经保护效果，它是通过阻止前半胱氨酸蛋白酶-1活化炎性细胞因子，白细胞介素-1β来起作用。
特點和優勢
该化合物是细胞凋亡研究的特色产品。点击此处 ，查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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