推荐产品
产品名称
Q-VD-OPh 水合物, ≥95% (HPLC)
化驗
≥95% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to light brown
溶解度
DMSO: ≥14 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
O=C(NC(C(C)C)C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)=O)C2=NC3=CC=CC=C3C=C2.[H]O[H]
InChI
1S/C26H25F2N3O6.H2O/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28;/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34);1H2/t20-,23-;/m0./s1
InChI 密鑰
ONOTWLLTFZMERH-WCRWPNQISA-N
應用
Q-VD-OPh水合物已用于：
- 作为泛胱天蛋白酶抑制剂防止细胞(UCC)死亡
- 诱发UC细胞中典型的胱天蛋白酶依赖细胞凋亡
- 抑制胱天蛋白酶3和多聚ADP-核糖聚合酶1(PARP-1)
- 研究人表皮细胞中EspZ效应蛋白抗细胞凋亡和坏死的保护作用
生化／生理作用
Q-VD-OPh是一种有效的泛半胱天冬酶抑制剂，可保护细胞免于半胱天冬酶依赖性细胞凋亡。 Q-VD-OPh的水稳定性、细胞渗透性和功效优于基于FMK的半胱天冬酶抑制剂，且单用无细胞毒性。
特點和優勢
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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