SMB00287

间型霉素 A

from Streptomyces kaniharaensis, ≥98% (HPLC)

• 别名: 1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-(1S)-D-Ribitol, 7-Amino-3-(β-D-ribofuranosyl)-1H-pyrazolo[4,3-d]pyrimidine, 8-Aza-9-deazaadenosine, Formycin, NSC 102811
• 经验公式（希尔记法）: C₁₀H₁₃N₅O₄
• CAS号: 6742-12-7
• 分子量: 267.24
• Beilstein: 624229
• MDL號碼: MFCD00036807
• 分類程式碼代碼: 51102829
• PubChem物質ID: 329824924
• NACRES: NA.85

属性

• 生物源: Streptomyces kaniharaensis
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place.)
• 顏色: white to off-white
• 溶解度: DMSO: soluble 1 mg/mL; H₂O: soluble 3 mg/mL
• 抗生素活性譜: viruses (Antiretroviral)
• 作用方式: enzyme | inhibits
• 儲存溫度: −20°C
• SMILES 字串: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI 密鑰: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• 基因資訊: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

说明

一般說明

Chemical structure: nucleoside

Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase.

生化／生理作用

Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP).

Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription.

Formycin A possess antitumor function, along with its antibacterial and antiviral activity.

包裝

10MG

其他說明

Keep container tightly closed in a dry and well-ventilated place.

Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable