推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 48 kDa
物種活性
rat, human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer422)
基因資訊
human ... SGK1(6446)
一般說明
The serum- and glucocorticoid-regulated kinase (Sgk1) is a member of the AGC kinase family. It is located on human chromosome 6q23.
免疫原
The antiserum was produced against synthesized peptide derived from human SGK around the phosphorylation site of Ser422.
Immunogen Range: 381-430
Immunogen Range: 381-430
生化／生理作用
The serum- and glucocorticoid-regulated kinase (Sgk1) controls ENaC (expressed renal epithelial Na+ channel) by mineralocorticoids. SGK1 controls p27 phosphorylation upon the activation by mTOR-Raptor.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Saniya Ossikbayeva et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Anticancer activities of plant polyphenols have been demonstrated in various models of neoplasia. However, evidence obtained in numerous in vitro studies indicates that proliferation arrest and/or killing of cancer cells require quite high micromolar concentrations of polyphenols that are difficult
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
Ellison DW, et al.
Journal of Clinical Oncology, 29(11), 1400-1407 (2011)
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
Hong F, et al.
Molecular Cell, 30(6), 701-711 (2008)
Impaired renal Na(+) retention in the sgk1-knockout mouse
Wulff P, et al.
The Journal of Clinical Investigation, 110(9), 1263-1268 (2002)
Bidisha Saha et al.
Journal of cell science, 135(23) (2022-11-15)
Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has well-characterized roles in mediating hormone and growth factor effects on a wide array
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