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抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
描述
Research area: Microbiome
形狀
buffered aqueous solution
物種活性
E. coli, Shigella flexneri
包裝
antibody small pack of 25 μL
濃度
~1.0 mg/mL
技術
immunoblotting: 0.5-1 μg/mL using E. coli lysate.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
Escherichia coli K12 ... ompT(945185)
Shigella flexneri ... ompT(1238162)
相关类别
一般說明
大肠杆菌蛋白酶-7，也称为Omptin(ompT)或外膜蛋白3B，属于外膜蛋白酶的omptin家族，存在于肠杆菌科的革兰氏阴性菌中。Omptin蛋白酶家族的独特性在于，具有丝氨酸和天冬氨酸蛋白酶的双重活性。某些家族成员可能还具有半胱氨酸蛋白酶和金属蛋白酶活性，均分享一个相同的保守活性位点。酶的蛋白水解活性依赖与脂多糖(LPS)脂质A部分的相互作用。
免疫原
对应大肠杆菌蛋白酶7 N末端部分、与KLH偶联的合成肽。
應用
抗-蛋白酶7抗体专一性识别大肠杆菌和福氏志贺氏菌来源的蛋白酶-7，不与奇异变形杆菌交叉反应。该抗体可用于各种免疫化学技术，包括免疫印迹（双联体~35 kDa）。
外觀
本品为溶于0.01M磷酸盐缓冲液的溶液形式，pH 7.4，含有15 mM叠氮化钠作为防腐剂。
免責聲明
本产品仅供研&发使用，不得用于药物、家庭或其他用途。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
L Vandeputte-Rutten et al.
The EMBO journal, 20(18), 5033-5039 (2001-09-22)
OmpT from Escherichia coli belongs to a family of highly homologous outer membrane proteases, known as omptins, which are implicated in the virulence of several pathogenic Gram-negative bacteria. Here we present the crystal structure of OmpT, which shows a 10-stranded
Akiko Urashima et al.
Cellular microbiology, 19(11) (2017-06-18)
Antimicrobial peptides (AMPs) are important components of the innate immune system. Enterohaemorrhagic Escherichia coli (EHEC), a food-borne pathogen causing serious diarrheal diseases, must overcome attack by AMPs. Here, we show that resistance of EHEC against human cathelicidin LL-37, a primary
Jenny-Lee Thomassin et al.
Infection and immunity, 80(2), 483-492 (2011-12-07)
Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) are food-borne pathogens that cause serious diarrheal diseases. To colonize the human intestine, these pathogens must overcome innate immune defenses such as antimicrobial peptides (AMPs). Bacterial pathogens have evolved various mechanisms
John R Brannon et al.
Infection and immunity, 83(6), 2300-2311 (2015-04-01)
Bacterial proteases are important virulence factors that inactivate host defense proteins and contribute to tissue destruction and bacterial dissemination. Outer membrane proteases of the omptin family, exemplified by Escherichia coli OmpT, are found in some Gram-negative bacteria. Omptins cleave a
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