推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 130-160 kDa
物種活性
human
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 2.5-5 μg/mL using paraformaldehyde fixed HEK-293T cells.
western blot: 2-4 μg/mL using HeLa nuclear cell lysates.
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RNASEN(29102)
一般說明
Drosha ribonuclease III (Drosha) is encoded by the gene mapped to human chromosome 5p13.3. It is a double-stranded RNA (dsRNA)-specific RNase III enzyme. The encoded protein contains RNase III domains (RIIIDs) on the top and central domain (CED) at the bottom. In addition, it also contains unique non-canonical zinc-finger motifs.
應用
Anti-Drosha antibody produced in rabbit has been used in western blotting and immunofluorescence.
生化／生理作用
Drosha ribonuclease III (Drosha) plays a vital role in initiation of microRNA (miRNA) maturation. It catalyzes the cleavage of stem loop structure from the primary microRNA (pri-miRNA).Drosha ribonuclease III (Drosha) plays a vital role in initiation of microRNA (miRNA) maturation. It catalyzes the cleavage of stem loop structure from the primary microRNA (pri-miRNA). Mutation in the gene is associated with development of Epithelial ovarian cancer (EOC). Knockdown of Drosha can enhance the sensitivity of gastric cancer to epirubicin.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A novel role for GSK3? as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
Fletcher CE
Nucleic Acids Research (2016)
[Knockdown of Drosha promotes chemosensitivity of epirubicin for gastric cancer MGC-803 cells].
Xu L
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32, 1207-1211 (2016)
Niya L Morris et al.
Biochimica et biophysica acta, 1863(10 Pt B), 2645-2653 (2017-04-14)
Ethanol exposure at the time of burn injury is a major contributor to post-burn pathogenesis. Many of the adverse effects associated with ethanol and burn injury are linked to an impaired intestinal barrier. The combined insult causes intestinal inflammation, resulting
Xiaoxiao Zhang et al.
Biochimica et biophysica acta, 1860(12), 1179-1188 (2017-11-08)
microRNAs (miRNAs) are first transcribed as long, primary transcripts, which are then processed by multiple enzymes and proteins to generate the single-stranded, approximately 22-nucleotide (nt)-long mature miRNAs. A critical step in animal miRNA biogenesis is the cleavage of primary miRNA
Structure of Human DROSHA.
Kwon SC
Cell, 164, 81-90 (2016)
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