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Merck

S8071

Sigma-Aldrich

丹酚 A

≥98% (HPLC), solid

别名:

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(乙酰氧基)-2-(3-呋喃基)十二氢-6a,10b-二甲基-4,10-二氧代-2H-萘[2,1 -c]吡喃-7-羧酸甲酯

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About This Item

经验公式(希尔记法):
C23H28O8
CAS号:
分子量:
432.46
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

儲存條件

protect from light

顏色

white

溶解度

DMSO: ≥10 mg/mL
ethanol: ~3 mg/mL

儲存溫度

−20°C

SMILES 字串

[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

InChI 密鑰

OBSYBRPAKCASQB-AGQYDFLVSA-N

基因資訊

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應用

给予大鼠Salvinorin A来研究其对乳酸刺激的拉伸的影响。1

生化/生理作用

Salvinorin A是一种有效的无氮κ阿片类选择性受体激动剂。Salvinorin A分离自墨西哥鼠尾草。Salvinorin A在天然(Ki = 4.3 nm)和克隆的(Ki = 16 nm)κ -阿片受体上均表现出高亲和力。初步研究表明,Salvanorin A在精神药物中具有独特的化学性质并不与任何已知受体结合。

特點和優勢

《受体分类和信号转导》手册的 阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

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Diansan Su et al.
Anesthesia and analgesia, 114(1), 200-204 (2011-11-15)
Cerebral hypoxia/ischemia during infant congenital heart surgery is not uncommon and may induce devastating neurologic disabilities persistent over the lifespan. Hypoxia/ischemia-induced cerebrovascular dysfunction is thought to be an important contributor to neurological damage. No pharmacological agents have been found to
Cécile Béguin et al.
Bioorganic & medicinal chemistry letters, 22(2), 1023-1026 (2011-12-30)
The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial
Melissa A Bodnar Willard et al.
Analytical and bioanalytical chemistry, 402(2), 843-850 (2011-12-14)
Salvia divinorum is a plant material that is of forensic interest due to the hallucinogenic nature of the active ingredient, salvinorin A. In this study, S. divinorum was extracted and spiked onto four different plant materials (S. divinorum, Salvia officinalis
Kimberly M Lovell et al.
Bioorganic & medicinal chemistry, 20(9), 3100-3110 (2012-04-03)
Modification of the furan ring of salvinorin A (1), the main active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. Conversion of the furan ring to an aldehyde at the C-12 position
Fang Ji et al.
Brain research, 1490, 95-100 (2012-10-30)
Since herkinorin is the first non-opioid mu agonist derived from salvinorin A that has the ability to induce cerebral vascular dilatation, we hypothesized that herkinorin could have similar vascular dilatation effect via the mu and kappa opioid receptors and the

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