RAB1317

人组织蛋白酶D ELISA

for serum, plasma and cell culture supernatants

• 别名: Cathepsin D
• 分類程式碼代碼: 41116158
• NACRES: NA.32

属性

• 物種活性: human
• 包裝: kit of 96 wells (12 strips x 8 wells)
• 技術: ELISA: suitable
• 輸入: sample type cell culture supernatant(s); sample type plasma; sample type serum
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 50 pg/mL; standard curve range: 0.049-12 ng/mL
• 檢測方法: colorimetric
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... CTSD(1509)

说明

一般說明

This ELISA antibody pair detects human Cathepsin D. Other species not yet determined.

應用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生化／生理作用

Cathepsin D encoded by CTSD gene, is an aspartyl protease, plays a major role in degradation of intracellular and endocytosed protein, for maintenance of tissue homeostasis and metabolism. Cathepsin D works as an endopeptidase in the acidic environment of lysosomes. Cathepsin D is part of signal transduction and a potential target for various cancer. Increased levels of Cathepsin D is associated with type 2 diabetes. Cathepsin D regulates sphingolipid metabolism and cholesterol trafficking. Genetic variations in Cathepsin D gene is a risk factor for Alzheimer′s disease and neuronal ceroid lipofuscinosis. Cathepsin D is a key marker in atherosclerosis and level of expression is increased in atherosclerotic lesions. Cathepsin D regulates the degradation of advanced glycation end products (AGEs) and impaired activity of cathepsin D results in accumulation of AGEs in photoaged skin. Increased plasma concentration of Cathepsin D causes non-alcoholic steatohepatitis (NASH) leading to hepatic lipid accumulation and inflammation.

其他說明

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

安全信息

• 象形圖: GHS05
• 訊號詞: Warning
• 危險聲明: H290
• 防範說明: P234 - P390
• 危險分類: Met. Corr. 1
• 儲存類別代碼: 8A - Combustible corrosive hazardous materials
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable