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Merck

R8526

Sigma-Aldrich

RO-52 (SSA) human

recombinant, expressed in E. coli, liquid

别名:

Anti-RO-52 antibody

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.56

生物源

human

品質等級

重組細胞

expressed in E. coli

形狀

liquid

分子量

52 kDa by SDS-PAGE

技術

ELISA: suitable

UniProt登錄號

儲存溫度

−70°C

基因資訊

human ... TRIM21(6737)

一般說明

Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.

應用

RO-52 (SSA) human has been used:
  • as a component of the autoantigen array
  • to immobilise protein on the self-assembly monolayer
  • in enzyme-linked immunosorbent assays (ELISAs)

生化/生理作用

RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

外觀

solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Anti-ro52 antibodies and interstitial lung disease in connective tissue diseases excluding scleroderma
Ferreira J, et al.
ISRN rheumatology, 2012, 415-421 (2012)
Autoantigen TRIM21/Ro52 as a possible target for treatment of systemic lupus erythematosus
Yoshimi R, et al.
International journal of rheumatology, 2012, 6277-6285 (2012)
Electronic Structure Calculation and Superconductivity in lambda-(BETS) 2GaCl4
Aizawa H, et al.
Journal of the Physical Society of Japan, 87(9), 093701-093701 (2018)
Serological epitope profile of anti-Ro52-positive patients with systemic autoimmune rheumatic diseases
Infantino M, et al.
Arthritis Research & Therapy, 17(1), 365-365 (2015)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)

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