J4144

Jo-1 human

recombinant, expressed in E. coli, solution

• MDL號碼: MFCD03457272
• 分類程式碼代碼: 12352204
• NACRES: NA.83

属性

• 重組細胞: expressed in E. coli
• 品質等級: 200
• 形狀: solution
• 分子量: 55 kDa by SDS-PAGE
• UniProt登錄號: P12081
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... HARS(3035)

说明

一般說明

Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity.

生化／生理作用

The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyositis patients.

Used in the immunoassay for antibodies to Jo-1.

外觀

Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable