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一般說明
肌酸激酶(CK)由 M 和 B 亚基组成,是一种二聚合分子。它是一种 CK 同工酶。这种酶主要存在于心肌中。
應用
与冠状动脉功能相关的酶。
肌酸激酶 MB 同工酶 (MBCK) 可作为急性心肌梗死的诊断标志物。
生化/生理作用
肌酸激酶(CK)可催化从磷酸肌酸形成肌酸酐。CK-MB 血清水平升高是心肌细胞损伤的主要指标,被视作心肌梗死诊断的“金标准”。心肌肌钙蛋白 I(cTnI)或心肌肌钙蛋白 I 的水平也与 CK-MB 水平升高相关。慢性肾衰竭时 CK-MB 的水平也可能升高。
成分
溶于 5 mM 琥珀酸钠、10 mM 氯化钠、1 mM EDTA、5 mMβ-巯基乙醇,50% 甘油,pH 7.0。
其他客户在看
Creatine Kinase
Clinical Methods: The History, Physical, and Laboratory Examinations (1990)
Annals of clinical and laboratory science, 32(1), 44-49 (2002-02-19)
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin
Clinical chemistry, 40(7 Pt 1), 1291-1295 (1994-07-01)
Although measurement of cardiac troponin I (cTnI) is, in some situations, more specific for detection of cardiac injury than is measurement of the MB isoenzyme of creatine kinase (MBCK), its sensitivity and specificity relative to MBCK for detection of myocardial
The American journal of cardiology, 87(12), 1356-1360 (2001-06-09)
We evaluated the short- and long-term clinical outcomes of 326 consecutive patients with chronic renal failure, not on dialysis, who had creatine kinase (CK)-myocardial band (MB) fraction elevation after successful percutaneous coronary intervention in a native coronary artery. Based on
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