推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
9H10, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~34 kDa
物種活性
human, hamster, monkey, rat, bovine, mouse, canine
技術
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using total cell extract of 293T cells
同型
IgG2b
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HNRNPA1(3178)
mouse ... Hnrnpa1(15382)
rat ... Hnrnpa1(29578)
一般說明
hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) is a pre-mRNA/mRNA binding protein, that belongs to the hnRNP family. It is located in chromosome 12q13.1. It is located in the nucleoplasm but it travels between the nucleus and the cytoplasm. It has two RNP motif RNA-binding domains (RBDs) at the amino terminus and a glycine-rich domain at the carboxyl terminus.
免疫原
purified human hnRNP-A1.
應用
Anti-hnRNP-A1 has been used in immunofluorescence, immunohistochemistry and western blotting.
Does not immunoprecipitate the hnRNP complex.
Does not immunoprecipitate the hnRNP complex.
生化／生理作用
hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) participates in several RNA metabolisms. It also participates in deep vein thrombosis patients with behçet′s disease. hnRNPA1 mutations results in amyotrophic lateral sclerosis and multisystem proteinopathy.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus
Liu C and Gotz J
PLoS ONE, 8(12) (2013)
Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients
Lee S and Levin M
F1000Research, 3:132 (2014)
hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic
Suzuki H and Matsuoka M
Molecular and Cellular Biochemistry, 427(1-2), 123-131 (2017)
HnRNP A1 is Involved in Deep Vein Thrombosis Patients with Behcet's Disease
Chen P, et al.
EBioMedicine, 6, 215-221 (2016)
A nuclear localization domain in the hnRNP A1 protein
Siomi H and Dreyfuss G
The Journal of Cell Biology, 129(3), 551-560 (1995)
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