Q0875

Quinidine sulfate salt dihydrate

• 经验公式（希尔记法）: C₄₀H₄₈N₄O₄ · H₂O₄S · 2H₂O
• CAS号: 6591-63-5
• 分子量: 782.94
• EC號碼: 200-046-3
• MDL號碼: MFCD00149346
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277870
• NACRES: NA.77

属性

• 雜質: ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
• mp: 212-214 °C (dec.) (lit.)
• 起源: Bayer
• SMILES 字串: [H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
• InChI 密鑰: ZHNFLHYOFXQIOW-WFTMRWCJSA-N

说明

一般說明

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

應用

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

生化／生理作用

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.

IA 类抗心律失常药；钾通道阻断剂。

特點和優勢

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves