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product name
CP-456773 钠盐, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
H2O: 20 mg/mL, clear
儲存溫度
room temp
SMILES 字串
CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]
InChI
1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChI 密鑰
LFQQNXFKPNZRFT-UHFFFAOYSA-M
應用
CP-456773钠盐已用于：
- 在体内实验中研究生酮饮食的神经保护作用。
- 研究抑制 NLRP3（nod样受体蛋白3）炎性体活性对小鼠模型肿瘤进展的影响。
- 研究胆固醇晶体介导的IL-1b（白细胞介素-1b）在胎盘外植体中的反应。
生化／生理作用
CP-456773钠盐（CRID3）是一种细胞因子释放抑制药物，也是NLRP3 炎性体的抑制剂。CP-456773钠盐抑制白细胞介素1β（IL-1β）分泌和caspase 1 加工。
已知 CP-456773抑制其他促炎细胞因子（如IL-1α和IL-18）的释放。它也被称为MCC950。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Haining Wang et al.
Life sciences, 227, 101-113 (2019-04-20)
NLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was
G S Stødle et al.
Clinical and experimental immunology, 193(1), 84-94 (2018-04-24)
Pre-eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger-sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1β and result
Cong-Fa Huang et al.
Journal of experimental & clinical cancer research : CR, 36(1), 116-116 (2017-09-04)
NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CSCs) of squamous cell carcinoma of the head and neck
Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress.
Guo M, et al.
Frontiers in Molecular Neuroscience, 11, 86-86 (2018)
Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation.
Primiano M J, et al.
Journal of Immunology, 197(6), 2421-2433 (2016)
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