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![1H-[1,2,4]恶二唑并[4,3-a]喹恶啉-1-酮 powder](/deepweb/assets/sigmaaldrich/product/structures/764/715/605dc5a5-0864-471b-a71e-bd2aa6553c1d/640/605dc5a5-0864-471b-a71e-bd2aa6553c1d.png)
化驗
≥98% (TLC)
形狀
powder
顏色
white to off-white
mp
180-182 °C (lit.)
溶解度
ethanol: 26 mg/mL
H2O: 50 mg/mL
起源
Novartis
SMILES 字串
CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI
1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI 密鑰
OGIYDFVHFQEFKQ-UHFFFAOYSA-N
基因資訊
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
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生化／生理作用
α-肾上腺素受体拮抗剂；外周血管舒张剂。
特點和優勢
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Darren P Casey et al.
Hypertension (Dallas, Tex. : 1979), 60(4), 1016-1022 (2012-09-06)
Aging is associated with increased retrograde and oscillatory shear in peripheral conduit arteries of humans. Although the mechanisms responsible for these age-related changes are not completely understood, augmented downstream α-adrenergic tone likely plays a significant role in this phenomenon. Therefore
Vijay Krishnamoorthy et al.
Anesthesiology, 117(4), 745-754 (2012-08-21)
Previous studies indicate epinephrine adversely affects arterial oxygenation when administered in a rat model of local anesthetic overdose. The authors tested whether epinephrine alone exerts similar effects in the intact animal. Anesthetized rats received a single intravenous injection of epinephrine
Travis Alvine et al.
The Journal of experimental biology, 216(Pt 5), 751-758 (2012-11-06)
We investigated sex differences in cardiovascular maturation in embryos of the snapping turtle Chelydra serpentina, a species with temperature-dependent sex determination. One group of eggs was incubated at 26.5°C to produce males. Another group of eggs was incubated at 26.5°C
K N Manolopoulos et al.
Diabetologia, 55(11), 3029-3037 (2012-08-18)
Fatty acid entrapment in femoral adipose tissue has been proposed to prevent ectopic fat deposition and visceral fat accumulation, resulting in protection from insulin resistance. Our objective was to test the hypothesis of femoral, compared with abdominal, adipose tissue resistance
Darren P Casey et al.
Journal of applied physiology (Bethesda, Md. : 1985), 113(8), 1201-1212 (2012-09-11)
We tested the hypothesis that elevated sympathetic tone is responsible for lower peak vasodilation after single muscle contractions in older adults. Young (n = 13, 7 men and 6 women, age: 27 ± 1 yr) and older (n = 13
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