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一般說明
Research area: Cell signalingPhosphodiesteraseI (PDEI) exists in three isoforms PDE1A,PDE1B, and PDE1C(2) that are locatedin cardiovascular, central nervous system, and other organs.
應用
本文用西方响尾蛇(Crotalus atrox)的磷酸二酯酶I分析了磷酸二酯酶I对中性粒细胞内钙浓度的影响。其也可与其他酶联合用于测定磷酸酶的活性。
磷酸二酯酶 (PDE) 是一种用来破坏磷酸二酯键的酶。磷酸二酯酶 I,产品 P4506 来自西部响尾蛇,用于磷酸二酯酶激活试验钙调素。加入该物质以水解AMP。其是一种膜结合糖蛋白,用于催化多种核苷酸多聚磷酸盐的水解。
生化/生理作用
磷酸二酯酶 I 破坏磷酸二酯键并催化各种核苷酸多磷酸盐的水解。通过磷脂酰肌醇特异性磷脂酶 C 从真核质膜释放磷酸二酯酶 I。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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Journal of biochemistry, 99(3), 703-712 (1986-03-01)
From various rat organs, alkaline phosphodiesterase I was liberated by the action of phosphatidylinositol-specific phospholipase C obtained from Bacillus thuringiensis. Especially, a large amount of alkaline phosphodiesterase I was released from slices of small intestine, testis, lung, and kidney, but
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Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function.
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One of the more complex developmental processes occurring postnatally in the CNS is the formation of the myelin sheath by oligodendrocytes. To examine the molecular events that take place during myelination, we isolated oligodendrocyte-derived cDNA clones, one of which (p421.HB)
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