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Merck

P2371

Sigma-Aldrich

帕米膦酸钠 二钠盐 水合物

≥95% (NMR), solid

别名:

3-氨基-1-羟基-1-膦酰基丙烷膦酸 二钠盐 水合物

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About This Item

经验公式(希尔记法):
C3H9NO7P2Na2 · xH2O
CAS号:
分子量:
279.03 (anhydrous basis)
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥95% (NMR)

形狀

solid

顏色

white

mp

300 °C

溶解度

H2O: 28 mg/mL

起源

Novartis

儲存溫度

2-8°C

SMILES 字串

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

InChI 密鑰

TVQNUQCYOOJTMK-UHFFFAOYSA-L

生化/生理作用

帕米膦酸二钠具有阻断Wnt和β-catenin信号转导的能力,其可调节骨髓间充质干细胞(BMMSC)的成骨分化。它还可以减少胆红素受损的细胞凋亡,并帮助了来自人乳牙的干细胞发育成牙本质功能障碍。
骨吸收抑制剂;法呢基二磷酸合酶的抑制剂(IC50= 200 nM)。

特點和優勢

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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