推荐产品
形狀
powder
包裝
pkg of 1 × 500 μg (860480P-500ug)
製造商／商標名
Avanti Polar Lipids 860480P
脂質類型
bioactive lipids
sphingolipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[NH3+]C(P([O-])(O)=O)(P(O)(O)=O)CCCCCCCCC
應用
C10 bisphosphonate is suitable for use as an inhibitor for acid sphingomyelinase.
生化／生理作用
C10 bisphosphonate, with prolonged carbon chain, is an inhibitor for acid sphingomyelinase and may be a treatment option for inflammatory lung diseases, cystic fibrosis and atherosclerosis. It interacts with the divalent metal ions and forms bidentate complexes. Bisphosphonates are inhibitors of end reaction in pathways. It is an inhibitor of cytosolic farnesyl diphosphate (FDP) synthase (geranyl diphosphate (GDP) and geranylgeranyl diphosphate (GGDP) synthase and isoprene pathway. Bisphosphonates have antimicrobial functionality and inhibits the growth of Entamoeba histolytica and Plasmodium falciparum.
包裝
5 mL Amber Glass Screw Cap Vial (860480P-500ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis
Novgorodov SA, et al.
Journal of Lipid Research, 59(2), 312-329 (2018)
Potent and selective inhibition of acid sphingomyelinase by bisphosphonates
Roth AG, et al.
Angewandte Chemie (International Edition in English), 48(41), 7560-7563 (2009)
Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen
Rasulov B, et al.
Plant Physiology, 168(2), 532-548 (2015)
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo
Ghosh S, et al.
Journal of Medicinal Chemistry, 47(1), 175-187 (2004)
Volker Teichgräber et al.
Nature medicine, 14(4), 382-391 (2008-04-01)
Microbial lung infections are the major cause of morbidity and mortality in the hereditary metabolic disorder cystic fibrosis, yet the molecular mechanisms leading from the mutation of cystic fibrosis transmembrane conductance regulator (CFTR) to lung infection are still unclear. Here
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