所有图片(2)
About This Item
线性分子式:
CH2O6Cl2Na2P2
CAS号:
分子量:
288.86
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.77
推荐产品
形狀
powder
品質等級
溶解度
water: 49.00-51.00 mg/mL, clear, colorless
儲存溫度
room temp
SMILES 字串
[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
InChI
1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChI 密鑰
HJKBJIYDJLVSAO-UHFFFAOYSA-L
基因資訊
rat ... Man2a1(25478) , Si(497756)
生化／生理作用
焦磷酸根类似物，抑制导致骨吸收和骨质疏松的破骨细胞活性。该化合物用于癌症研究，尤其是骨转移癌和乳腺癌。当包封在脂质体中时 ，用于巨噬细胞选择性耗竭（巨噬细胞“自杀”技术），尤其是在脾脏和肝脏中。还发现抑制胶原酶和基质金属蛋白酶 1。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Fabricio Montalvao et al.
The Journal of clinical investigation, 123(12), 5098-5103 (2013-11-02)
Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell depletion is not fully understood. In particular, the anatomical location, the type
A Lipton
Cancer, 80(8 Suppl), 1668-1673 (1997-11-15)
The skeleton is a common site of breast carcinoma metastasis; 75% of patients with breast carcinoma demonstrate bone metastases at autopsy. The lytic destruction of bone in these patients is due to excessive osteoclastic activity. By reducing osteoclastic activity, bisphosphonates
H A Fleisch
Annals of medicine, 29(1), 55-62 (1997-02-01)
The bisphosphonates are synthetic compounds characterized by a P-C-P bond. They have a strong affinity to calcium phosphates and hence to bone mineral. In vitro they inhibit both formation and dissolution of the latter. Many of the bisphosphonates inhibit bone
O Teronen et al.
Calcified tissue international, 61(1), 59-61 (1997-07-01)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an
Michiko Itoh et al.
PloS one, 8(12), e82163-e82163 (2013-12-19)
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门