推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
human, mouse, rat
技術
western blot: 1:200 using rat brain lysate and transfected cells HEK-KV10.1.
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... KCNH1(3756)
mouse ... Kcnh1(16510)
rat ... Kcnh1(65198)
一般說明
Human genome codes for 40 voltage-gated K+ channels (KV). Voltage-gated-like ion channels (VGICs) are the third largest group of signaling molecules found in humans. K+ channels can be divided into four structural types based on their number of transmembrane regions and mode of activation, namely Kir- the inwardly rectifying 2-transmembrane K+ channels, K2P- 2-pore 4-transmembrane K+ channels, KCa- Ca2+-activated 6-transmembrane or 7-transmembrane K+ channels, and KV- voltage-gated 6-transmembrane K+ channels. KCNH1 (potassium voltage-gated channel H1) is a KV channel and is also known as KV10.1. Like all KV members, it is composed of four α-subunits with each containing six transmembrane α-helical segments, and a membrane-re-entering P-loop. These surround a central pore as homotetramers or heterotetramers. KCNH1 mRNA and protein are both abundantly found in the brain, though its peripheral tissue expression is restricted. This gene is localized to human chromosome 1q32.1.
特異性
Specific for KV10.1 and does not cross react with KV10.2.
免疫原
peptide GDPAKRKGWARFKDAC corresponding to residues 802-817 of rat KV10.1. This sequence is identical in mouse and has 14/16 residues identical in human.
生化／生理作用
KCNH1 (potassium voltage-gated channel H1) initiates a slowly activating, non-inactivating K+ current in a heterologous system. In skeletal muscles, it is expressed only during the phase when myoblasts exit the cell cycle and fuse, and thus, it plays an essential role in skeletal muscle development. This protein is found to be expressed in ∼70% human cancers, including gastric, mammary tumors, colon carcinoma, and sarcomas. This channel is implicated in neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes.
標靶描述
Potassium Channel Kv10.1 (EAG-1) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming α-subunit of a voltage-gated non-inactivating delayed rectifier potassium channel.
外觀
Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Heike Wulff et al.
Nature reviews. Drug discovery, 8(12), 982-1001 (2009-12-02)
The human genome encodes 40 voltage-gated K(+) channels (K(V)), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulating Ca(2+) signalling and cell volume, to driving cellular proliferation and migration. K(V) channels
Voltage-gated potassium channels: from hyperexcitability to excitement.
Pongs O
Febs Letters, 452(1-2), 31-35 (1999)
Stephan Patt et al.
Neuroscience letters, 368(3), 249-253 (2004-09-15)
Ether à go-go (EAG) K(+) channels have been shown to be involved in tumor generation and malignant growth. Gliomas have not been investigated thus far. Using RT-PCR we investigated healthy human brain and human gliomas of different subtypes and malignancy
Chung-Jiuan Jeng et al.
Neuroreport, 16(3), 229-233 (2005-02-12)
Two isoforms of rat ether-a-go-go (Eag) K channels, rEag1 and rEag2, are widely expressed in many regions of the brain. The neurophysiological roles of these channels, however, are unclear. We addressed this issue by studying their subcellular localizations in hippocampal
Bo Han et al.
Scientific reports, 6, 23417-23417 (2016-03-24)
Voltage-gated ether à go-go (EAG) K(+) channels are expressed in various types of cancer cells and also in the central nervous system. Aberrant overactivation of human EAG1 (hEAG1) channels is associated with cancer and neuronal disorders such as Zimmermann-Laband and
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