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Merck

M6699

Sigma-Aldrich

山楂酸

≥98% (HPLC)

别名:

2α, 3β-二羟基-12-烯-28-酸, 2α-羟基齐墩果酸, 山楂酸

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About This Item

经验公式(希尔记法):
C30H48O4
CAS号:
分子量:
472.70
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.25

化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

acetone: 1 mg/mL, clear, colorless

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

2-8°C

SMILES 字串

CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O

InChI

1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20+,21-,22+,23-,27-,28+,29+,30-/m0/s1

InChI 密鑰

MDZKJHQSJHYOHJ-LLICELPBSA-N

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一般說明

山楂酸是一种五环三萜类化合物,最早从锐刺山楂中分离得到。 它主要来源于油橄榄,并存在于橄榄果渣的非甘油酯部分。

應用

山楂酸已被用于研究其对人肾细胞癌 (RCC) 细胞系和内皮细胞的抗增殖和抗血管生成作用。它还用作参考标准品,通过微波辅助萃取 (MAE) 法从橄榄果渣中提取三萜酸。

生化/生理作用

山楂酸是一种强效抗氧化剂和抗炎剂。除了是一种良好的抗癌剂外,它还具有抗糖尿病和抗寄生虫的特性。山楂酸具有神经保护和心脏保护作用。据报道它是一种针对恶性疟原虫的多靶点抗疟药。
在橄榄中发现的主要三萜类化合物。抗增殖。有前景的化学预防剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Parth Thakor et al.
Journal of kidney cancer and VHL, 4(1), 16-24 (2017-04-14)
Despite the introduction of many novel therapeutics in clinical practice, metastatic renal cell carcinoma (RCC) remains a treatment-resistant cancer. As red and processed meat are considered risk factors for RCC, and a vegetable-rich diet is thought to reduce this risk
Glòria Lozano-Mena et al.
Journal of agricultural and food chemistry, 60(41), 10220-10225 (2012-09-26)
Maslinic acid, a pentacyclic triterpene from olives, has been reported to exert beneficial effects on health, including anticarcinogenic activity. Despite its importance, little is known about its bioavailability in both humans and animals. A fundamental step for this evaluation consisted
Carlos Moneriz et al.
The FEBS journal, 278(16), 2951-2961 (2011-06-22)
Most drugs against malaria that are available or under development target a single process of the parasite infective cycle, favouring the appearance of resistant mutants which are easily spread in areas under chemotherapeutic treatments. Maslinic acid (MA) is a low
Yisong Qian et al.
European journal of pharmacology, 670(1), 148-153 (2011-08-16)
Maslinic acid is a triterpenoid compound present in plants of Olea europaea. This compound has been reported to have potent antioxidant, anti-cancer, anti-HIV and anti-inflammatory activities. In this study, we investigated the neuroprotective effect of maslinic acid and its mechanism
Susana Sánchez-Tena et al.
PloS one, 8(3), e59392-e59392 (2013-03-26)
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known

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