所有图片(1)
About This Item
经验公式（希尔记法）:
C15H24N2O7S
CAS号:
分子量:
376.43
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
产品名称
乳酸胱氨酸, ≥90% (HPLC)
品質等級
化驗
≥90% (HPLC)
形狀
powder
效力
4 nM Ki (proteasome inhibitor)
溶解度
water: 10 mg/mL, clear, colorless
儲存溫度
−20°C
SMILES 字串
CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O
InChI
1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
InChI 密鑰
DAQAKHDKYAWHCG-RWTHQLGUSA-N
一般說明
乳酸菌素作为一种抗生素，是链霉菌的代谢物。
應用
使用乳胞素：
- 作为蛋白酶体抑制剂，抑制蛋白质降解
- 抑制细胞蛋白酶体活性，为活细胞成像
- 阻断人单核细胞来源的树突状细胞(MoDC)中蛋白酶体蛋白水解长达24小时
- 对动物进行单侧注射，诱导黑纹状体病变
生化／生理作用
乳酸菌素在小鼠神经母细胞瘤细胞系中具有抑制细胞周期发育、刺激分化等作用。它可以作为Clasto-乳胞素β-内酯的前体。细胞可透过性和不可逆蛋白酶体抑制剂(Ki = 4nM)。抑制NF-kB的活化(IC50 = 10mM)。在neuro2A小鼠神经母细胞瘤细胞中诱导神经突生长。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin A CENTRAL ROLE FOR clasto-LACTACYSTIN beta-LACTONE
Dick L R, et al.
The Journal of Biological Chemistry, 271(13), 7273-7276 (1996)
The development and pharmacology of proteasome inhibitors for the management and treatment of cancer
Ruggeri B, et al.
Advances in Pharmacology, 57(13), 91-135 (2009)
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through Galphao/i-triggered proteasomal degradation of Rap1GAPII
Jordan J D, et al.
The Journal of Biological Chemistry, 280(12), 11413-11421 (2005)
Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease
Vernon A C, et al.
PLoS ONE, 6(2), e17269-e17269 (2011)
Dallas S Shi et al.
The Journal of clinical investigation, 124(9), 3757-3766 (2014-07-26)
The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of
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