所有图片(1)
About This Item
经验公式（希尔记法）:
C16H11BrN2O
CAS号:
分子量:
327.18
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98%
形狀
solid
顏色
yellow
溶解度
DMSO: 18 mg/mL, clear, yellow
儲存溫度
2-8°C
SMILES 字串
Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InChI
1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
InChI 密鑰
QQUXFYAWXPMDOE-UHFFFAOYSA-N
基因資訊
human ... CDC2(983)
mouse ... Gsk3b(56637)
rat ... Gsk3b(84027)
應用
Kenpaullone已被用作：
- 糖原合成酶激酶 3 (GSK3)/周期蛋白依赖性激酶(CDK)抑制剂，以研究对人类神经祖细胞系的影响
- Krupple类因子4 (KLF4)抑制剂，用于Gs-coupled designer GPCR (Gs DREADD= GsD)刺鼠相关肽(GsD-AgRP)小鼠
- GSK3/CDK抑制剂，以研究对海胆胚胎发育的影响。
生化／生理作用
Kenpaullone也是一种糖原合成酶激酶3β (GSK3β)的抑制剂。它还可抑制周期蛋白依赖性激酶1 (CDK1/cyclin B)、CDK2/cyclin A、CDK2/cyclin E和 CDK5/p25，主要通过三磷酸腺苷(ATP)结合的竞争性抑制。
包裝
在氩气环境中储存
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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