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Merck

I2526

Sigma-Aldrich

Insulin-like Growth Factor-II human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

IGF-II

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.77

product name

Insulin-like Growth Factor-II human, IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

生物源

human

品質等級

重組細胞

expressed in E. coli

化驗

≥98% (SDS-PAGE and HPLC)

形狀

lyophilized powder

效力

≤2.0 ng/mL ED50

品質

endotoxin tested

分子量

7.5 kDa

包裝

pkg of 5X50 μg
pkg of 50 μg

技術

cell culture | mammalian: suitable

雜質

≤0.1 EU/μg

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... IGF2(3481)

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生化/生理作用

Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.

外觀

Lyophilized from a 0.2 μm filtered solution with no additives.

分析報告

The biological activity is measured by a cell proliferation assay using mouse FDC-P1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Yongming Yuan et al.
Scientific reports, 7(1), 78-78 (2017-03-03)
Insulin-like growth factors (IGFs) regulate diverse processes including energy metabolism, cell proliferation and embryonic development. They activate the IGF signaling pathway via binding to cell surface receptors. Here we report an essential role of IGF2 in maintaining the pluripotency of
Jasmin Svinka et al.
Journal of molecular medicine (Berlin, Germany), 95(1), 109-117 (2016-08-29)
We have demonstrated that the signal transducer and activator of transcription 3 (STAT3) protects from cholestatic liver injury. Specific ablation of STAT3 in hepatocytes and cholangiocytes (STAT3∆hc) aggravated liver damage and fibrosis in the Mdr2-/- (multidrug resistance 2) mouse model
Till Seime et al.
Cells, 10(6) (2021-06-03)
Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signature of calcified plaques, expressed in smooth
Chun-Chang Yeh et al.
International journal of molecular sciences, 16(11), 27156-27170 (2015-11-19)
Pulsed radiofrequency (PRF) is effective in the treatment of neuropathic pain in clinical practice. Its application to sites proximal to nerve injury can inhibit the activity of extra-cellular signal-regulated kinase (ERK) for up to 28 days. The spared nerve injury

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Insulin-like Growth Factors (IGF)

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