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生物源
chicken
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
mouse, human, rat
製造商／商標名
Genway 15-288-21444
技術
immunocytochemistry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... M6PR(4074)
免疫原
Immunogen Sequence: GI # 4505061, sequence 60-114
Recombinant cation-dependent mannose-6-phosphate receptor
應用
Anti-M6PR antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化／生理作用
Mannose 6-phosphate receptor is an integral transmembrane glycoprotein encoded by the M6PR gene in humans. It is ubiquitously expressed and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. It is a 46kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and plays a key role in the delivery of lysosomal enzymes to the lysosome by binding newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and diverting them from the secretory pathway. M6PR plays a major role in cellular function by transporting Man-6-P-containing acid hydrolases from the Golgi to endosomal/lysosomal compartments.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
G G Sahagian et al.
The Journal of biological chemistry, 260(17), 9838-9842 (1985-08-15)
The mannose 6-phosphate (Man-6-P) receptor is an integral membrane glycoprotein which mediates intracellular transport and receptor-mediated endocytosis of lysosomal proteins. Clathrin-coated vesicles, which have been shown to be significantly involved in these processes, have also been shown to be a
Shelby C Bearrows et al.
Journal of cell science, 132(13) (2019-06-12)
Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules of multiple endocrine tissues and has been suggested to regulate granule biogenesis in some cell types, including the pancreatic islet β-cell, though the mechanisms are
Jung-Ja P Kim et al.
Current opinion in structural biology, 19(5), 534-542 (2009-10-06)
The two P-type lectins, the 46kDa cation-dependent mannose-6-phosphate (Man-6-P) receptor (CD-MPR), and the 300kDa cation-independent Man-6-P receptor (CI-MPR), are the founding members of the growing family of mannose-6-phosphate receptor homology (MRH) proteins. A major cellular function of the MPRs is
Seii Ohka et al.
Biology open, 11(9) (2022-08-06)
Enterovirus 71 (EV71) is one of the causative agents of hand-foot-and-mouth disease, which in some circumstances could lead to severe neurological diseases. Despite of its importance for human health, little is known about the early stages of EV71 infection. EV71
Linda J Olson et al.
Biochemistry, 49(1), 236-246 (2009-11-26)
The 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) plays a key role in the delivery of lysosomal enzymes to the lysosome by binding newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and diverting them from the secretory pathway. Previous studies on
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