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Merck
所有图片(1)

主要文件

G1794

Sigma-Aldrich

GAP-27

≥97% (HPLC)

别名:

Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

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About This Item

经验公式（希尔记法）:
C60H102N15O17
CAS号:
198284-64-9
分子量:
1305.54
MDL號碼:
MFCD03456920
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

品質等級

200

化驗

≥97% (HPLC)

形狀

powder

包裝

pkg of 2 mg

技術

cell culture | mammalian: suitable

溶解度

water: soluble 1.00-1.02 mg/mL, clear, colorless

UniProt登錄號

P35212

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C60H101N15O17/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76/h12-14,19-20,31-35,37-42,44-48,76-78H,9-11,15-18,21-30,61-62H2,1-8H3,(H,66,82)(H,67,88)(H,68,81)(H,69,86)(H,70,84)(H,71,89)(H,72,87)(H,73,83)(H,74,85)(H,79,80)(H,91,92)(H4,63,64,65)/t31-,32-,33-,34+,35+,37-,38-,39-,40-,41-,42-,44-,45-,46-,47-,48-/m0/s1

InChI 密鑰

SXRAPDIXXYFGJG-MDAHIHQXSA-N

基因資訊

human ... GJA4(2701)

Amino Acid Sequence

Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

應用

GAP-27已被用作FDC（卵泡树突状细胞）-B细胞培养物中Cx43（连接蛋白43）间隙连接的封闭肽。

生化／生理作用

GAP-27与连接蛋白的胞外环区域共享同源性，因此其被认为可抑制连接蛋白Cx32、Cx40和Cx43之间的连接。它可高度阻碍协作性细胞间相互作用，包括胚胎心肌细胞的协同跳动。该肽可降低破骨细胞活性和存活率。 该肽可显著减少乙酰胆碱介导的平滑肌细胞超极化。
内皮细胞中间隙连接信号的抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Shaun L Sandow et al.
Circulation research, 90(10), 1108-1113 (2002-06-01)
The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is controversial, putatively involving diffusible factors and/or electrotonic spread of hyperpolarization generated in the endothelium via myoendothelial gap junctions (MEGJs). In this study, we investigated the relationship between the existence of
Hajnalka Rajnai et al.
Journal of immunology research, 2015, 528098-528098 (2015-03-31)
Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicular lymphomas B cells escape apoptosis while FDC develop abnormally. Here we tested
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BMC musculoskeletal disorders, 2, 10-10 (2001-12-19)
Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and that a commonly used gap-junctional inhibitor, heptanol, can inhibit osteoclastic bone resorption. Since heptanol
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Therapeutic manipulation of regulatory T cells (Tregs) has been regarded as a promising approach for the treatment of immune disorders. However, a better understanding of the immunomodulatory mechanisms of Tregs and new safe and effective methods to improve the therapeutic

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