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Merck

G154

Sigma-Aldrich

加巴喷丁

≥98% (HPLC), solid, anticonvulsant

别名:

1-(氨甲基)-环己烷乙酸, 加巴喷丁

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About This Item

经验公式(希尔记法):
C9H17NO2
CAS号:
分子量:
171.24
Beilstein:
2359739
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

加巴喷丁, solid

形狀

solid

品質等級

顏色

off-white

溶解度

H2O: 10 mg/mL

SMILES 字串

NCC1(CC(O)=O)CCCCC1

InChI

1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

InChI 密鑰

UGJMXCAKCUNAIE-UHFFFAOYSA-N

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應用

加巴喷丁已被用于:
  • 作为 α2δ-配体,以检查异硫氰酸烯丙酯 (AITC) 敏化热厌恶试验是否可作为鉴别假定镇痛药的筛选方法
  • 溶于摄取缓冲液,使用液相色谱-质谱法通过有机阳离子转运蛋白 2 (OCTN2) 测定 ASP(反式-4-[4-(二甲氨基)苯乙烯基]-1-甲基吡啶碘)底物
  • 用作腹腔内注射的镇痛佐剂

生化/生理作用

作用机制不明的抗惊厥药;可通过血脑屏障;增加脑内 GABA 浓度,减少兴奋性氨基酸神经传递,可能是通过其对电压门控钙通道的作用;表现出抗伤害、抗焦虑、神经保护和抗癫痫作用。
加巴喷丁作为 L 型钙通道 α2δ 亚单位的配体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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