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化驗
≥98% (HPLC)
形狀
solid
溶解度
DMSO: >10 mg/mL
儲存溫度
room temp
SMILES 字串
Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4
InChI
1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1
InChI 密鑰
NJZHEQOUHLZCOX-FTLRAWMYSA-N
應用
杀真菌剂 A 可用作逆转录分析的抑制剂，并被用作 HeLa 细胞中高尔基体特异性布雷菲德菌素 A 抗鸟嘌呤核苷酸交换因子 1 蛋白（GBF1）的抑制剂。
生化／生理作用
Golgicide A 是一种有效的、高特异性的、可逆的顺式高尔基 体 ArfGEF GBF1 抑制剂。Arf 蛋白是介导小泡运输的小鸟苷三磷酸酶（GTPase）Ras 超家族的成员。Golgicide A 在 Arf1 和 GBF1 Sec7 结构域之间形成的界面裂缝内结合。Golgicide A 是一种独特而强大的工具，可用于进一步阐明高尔基体内组装和运输的机制，而 Dynasore 可用于研究动力蛋白介导的网格蛋白涂层形成动力学。
Golgicide A 是一种有效的、高特异性的、可逆的顺式高尔基体 ArfGEF GBF1 抑制剂。
特點和優勢
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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