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product name
9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α, solution, 10 mg/mL in methyl acetate
形狀
solution
品質等級
濃度
10 mg/mL in methyl acetate
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
CCCCC[C@H](O)\C=C\[C@H]1C2CC(CO2)[C@@H]1C\C=C/CCCC(O)=O
InChI
1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1
InChI 密鑰
LQANGKSBLPMBTJ-REGKDVDGSA-N
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一般說明
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α是一种内过氧化物/血栓素类似物。
應用
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α已用于：
- 诱导肌球蛋白轻链9（Myl9）基因缺失的小鼠的主动脉平滑肌（SM）收缩
- 诱导收缩作为小鼠主动脉血管反应性实验的一部分
- 作为血栓素/前列腺激动剂，以研究二硫苏糖醇（DTT）对小鼠动脉血管活性的影响
生化／生理作用
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α是一种血栓素A2激动剂。它可在体外实验中诱导血小板的形状变化、凝集、分泌、磷酸肌醇水解和蛋白质磷酸化。它还会引起胞质Ca++水平的升高，轻微影响环磷酸腺苷（cAMP）的形成。它可用作血管细胞粘附分子-1（VCAM-1）的有效刺激因子，以介导白细胞粘附至内皮细胞。
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
標靶器官
Central nervous system
安全危害
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
14.0 °F
閃點（°C）
-10 °C
個人防護裝備
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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