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Merck

A2661

Sigma-Aldrich

氯化乙酰胆碱

suitable for cell culture

别名:

ACh

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About This Item

线性分子式:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS号:
分子量:
181.66
Beilstein:
3571875
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32190102
PubChem物質ID:
NACRES:
NA.75

生物源

synthetic

品質等級

化驗

~99%

形狀

powder

技術

cell culture | mammalian: suitable

mp

146-150 °C (lit.)

溶解度

water: 100 mg/mL, clear, colorless

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

[Cl-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChI 密鑰

JUGOREOARAHOCO-UHFFFAOYSA-M

基因資訊

human ... CHRM3(1131)

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應用

氯化乙酰胆碱已用于制备乙酰胆碱,是乙酰胆碱(ACh)离子导入的常用溶媒。它还用于处理aNS-1来源神经元以进行cAMP(环腺苷单磷酸)分析,也用于检测其对G蛋白偶联受体(GPCR)的影响作用。

生化/生理作用

氯化乙酰胆碱,20mg/kg体重注射,减少小鼠实验性诱发脓毒病的死亡和血浆促炎细胞因子。类胆碱能抗-炎症机制可能通过乙酰胆碱和 α7n单核细胞,巨噬细胞和中性粒细胞上的胆红素受体互作接待,降低了促炎细胞活素,比如 TNF-α,IL-1β,和IL-6。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library
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