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品質等級
化驗
≥98% (HPLC)
形狀
powder
mp
184 °C
溶解度
chloroform: 10 mg/mL
ethanol: soluble
應用
diagnostic assay manufacturing
hematology
histology
儲存溫度
2-8°C
SMILES 字串
CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13
InChI
1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
InChI 密鑰
NNJPGOLRFBJNIW-HNNXBMFYSA-N
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應用
Demecolcine has been used as a microtubule depolymerizing agent. It has also been used to inhibit mitotic division.
生化／生理作用
通常在核型分析和细胞周期研究中，其可在细胞周期的特定阶段增加有丝分裂细胞的产量。这可以通过多种方式来实现，其中最流行的是使用细胞周期同步剂，例如地美考辛。地美考辛会将细胞停滞于中期，同时对有丝分裂细胞或经同步的G1和S期细胞中的生化事件无明显影响。经常会用地美可辛处理白细胞以阻止中期细胞。
包裝
Bottomless glass bottle. Contents are inside inserted fused cone.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
The Drosophila microtubule-associated protein mars stabilizes mitotic spindles by crosslinking microtubules through its N-terminal region.
Zhang G, et al.
PLoS ONE, 8, e60596-e60596 (2013)
Flow cytometric discrimination of mitotic nuclei by right-angle light scatter.
Zucker RM, et al.
Cytometry, 9, 226-231 (1988)
Gang Zhang et al.
Journal of cell science, 122(Pt 4), 535-545 (2009-01-29)
The formation of the mitotic spindle is controlled by the microtubule organizing activity of the centrosomes and by the effects of chromatin-associated Ran-GTP on the activities of spindle assembly factors. In this study we show that Mars, a Drosophila protein
Mathew J Thayer
BioEssays : news and reviews in molecular, cellular and developmental biology, 34(9), 760-770 (2012-06-19)
Recent studies indicate that mammalian chromosomes contain discrete cis-acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non-coding RNA gene ASAR6 results in late replication, an under-condensed appearance during mitosis, and structural
Nuno Costa-Borges et al.
Theriogenology, 75(3), 527-541 (2010-11-16)
Treatment of pre-activated oocytes with demecolcine (DEM) has been shown to induce the extrusion of all oocyte chromosomes within the second polar body (PB2). However, induced enucleation (IE) rates are generally low and the competence of these cytoplasts to support
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