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Merck

C7505

Sigma-Aldrich

L -胱硫醚

≥98% (TLC), suitable for UHPLC

别名:

( R )-S-(2-氨基-2-羧乙基)- L -同型半胱氨酸

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About This Item

经验公式(希尔记法):
C7H14N2O4S
CAS号:
分子量:
222.26
Beilstein:
2505200
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

product name

L -胱硫醚, ≥98% (TLC)

化驗

≥98% (TLC)

形狀

powder

技術

UHPLC: suitable

顏色

white

mp

>300 °C

儲存溫度

−20°C

SMILES 字串

N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O

InChI

1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1

InChI 密鑰

ILRYLPWNYFXEMH-WHFBIAKZSA-N

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應用

L-胱硫醚已被用于超高效液相色谱中,用于验证胱硫醚及其丰度与脊椎动物变态的相关性。 它还被用作窦状GSH(谷胱甘肽)载体的抑制剂,以表明巯基氧化还原状态失衡与癌细胞中自噬的调节有关。

生化/生理作用

L-胱硫醚是 L-半胱氨酸和蛋氨酸生物合成的中间体。 作为底物用于分化分析胱硫醚 γ-裂解酶。L-胱硫醚是一种重要的非蛋白氨基酸,与代谢紊乱有关。在最近的研究中,L-胱硫醚被认为是环亚氨基环硫氨酸的前体。胱硫醚尿症的特征是尿中排出亚氨基酸环硫氨酸。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase.
Ricci G
European Journal of Biochemistry, 157(1), 57-63 (1986)
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The two disulfide bonds of α-conotoxin ImI, a peptide antagonist of the α7 nicotinic acetylcholine receptor (nAChR), were systematically replaced with isosteric redox-stable cystathionine thioethers. Regioselective thioether formation was accomplished on solid support through substitution of a γ-chlorohomoalanine by an

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