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D5011

Sigma-Aldrich

5′-脱氧-5′-腺苷

别名:

甲硫腺苷, MTA

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About This Item

经验公式（希尔记法）:
C11H15N5O3S
CAS号:
2457-80-9
分子量:
297.33
Beilstein:
42420
MDL號碼:
MFCD00010533
分類程式碼代碼:
41106305
PubChem物質ID:
24893915
NACRES:
NA.51

生物源

synthetic (organic)

品質等級

200

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

儲存溫度

−20°C

SMILES 字串

CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

InChI 密鑰

WUUGFSXJNOTRMR-IOSLPCCCSA-N

基因資訊

human ... ADORA2B(136) , ADORA3(140)
mouse ... Mtap(66902)
rat ... Adora1(29290) , Adora2a(25369)

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相关类别

應用

5′-脱氧-5′-(甲硫基)腺苷已被用作蛋白质甲基化抑制剂，可降低肝细胞癌(HCC)细胞中的E2F转录因子1（E2F1）蛋白丰度。这种成分还用于抑制组蛋白甲基化修饰，研究其在缺氧诱导因子1(Hif-1)核转运中的作用。

生化／生理作用

5′-脱氧-5′-（甲硫基）腺苷（甲硫腺苷）可用作底物来研究5′-甲硫腺苷磷酸化酶（MTAP）（EC2.4.2.28）的特异性和动力学，该酶是一个肿瘤抑制基因所表达的酶，其可支持S-腺苷甲硫氨酸（AdoMet）和蛋氨酸补救途径。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
SLCM3932
SLCJ6644
SLCF0509
SLCC4330
SLCB5578

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