所有图片(1)
About This Item
经验公式（希尔记法）:
C8H20NO4P · xH2O
CAS号:
分子量:
225.22 (anhydrous basis)
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥97% (NMR)
形狀
solid
儲存條件
desiccated
顏色
white
溶解度
H2O: >20 mg/mL
起源
Novartis
儲存溫度
−20°C
SMILES 字串
O.CCOC(OCC)P(O)(=O)CCCN
InChI
1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
InChI 密鑰
SRBHGEXMDCJOMS-UHFFFAOYSA-N
應用
CGP 35348水合物已用作γ-氨基丁酸-B (GABAB)受体抑制剂：
- 用于研究其对大鼠海马体内源光信号(IOS)的影响
- 通过单独使用或与水杨酸钠联用，研究其对大鼠背皮层听觉反应的影响
- 研究其对肝细胞癌细胞(HCC)的影响
生化／生理作用
CGP 35348是一种γ-氨基丁酸-B (GABAB)受体拮抗剂。它可穿过血脑屏障，对突触后受体的亲和性比突触前受体更高。
特點和優勢
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
注意
产品具有吸湿性
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
GABAB receptor antagonists: from synthesis to therapeutic applications.
H Bittiger et al.
Trends in pharmacological sciences, 14(11), 391-394 (1993-11-01)
Miguel A Cortez et al.
Pediatric research, 65(5), 499-503 (2009-02-05)
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hypothesis that
S E Sander et al.
Neuroscience, 162(2), 423-430 (2009-05-12)
The GABA(B) receptor (GABA(B)R) agonist baclofen is known to have a beneficial potency in patients who suffer from dystonia, a neurological syndrome characterized by involuntary co-contractions of opposing muscles. The underlying mechanisms of this movement disorder are still unclear. Previous
Pavel Mareš
Epilepsy research, 92(2-3), 125-133 (2010-09-25)
Epileptic seizures activate not only excitatory but also inhibitory systems what results in an arrest of seizures. Our recent data indicate that GABAergic inhibition plays an important role in this process in cortically elicited seizures. We started to study the
K R Delaney et al.
The European journal of neuroscience, 30(11), 2077-2088 (2010-02-05)
Synaptic responses resulting from stimulation of the main olfactory and vomeronasal (VN) nerves were measured in main and accessory olfactory bulb (AOB) of frog, Rana pipiens, to test the hypothesis that properties of these synapses would reflect the distinct differences
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