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Merck
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Key Documents

SML0593

Sigma-Aldrich

CGP52432

≥98% (HPLC)

别名:

[3-[[（3,4-二氯苯基）甲基]氨基]丙基]（二乙氧基甲基）次膦酸

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About This Item

经验公式（希尔记法）:
C15H24Cl2NO4P
CAS号:
139667-74-6
分子量:
384.24
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 1 mg/mL, clear (warmed)

儲存溫度

2-8°C

InChI

1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)

InChI 密鑰

GJZVQXWEIYRHBE-UHFFFAOYSA-N

應用

CGP52432已用作γ-氨基丁酸B(GABAB)拮抗剂：
  • 研究其对小鼠癫痫持续状态(SE)发作刺激的影响
  • 用于小鼠神经元的电压钳记录
  • 研究其对豚鼠海马体中GABAB受体介导神经传递的影响

生化／生理作用

CGP52432可抑制海马体中的甘氨酸溢流。
CGP52432是一种非常强效的GABAB受体拮抗剂。（IC50 = 85 nM）。

特點和優勢

《受体分类和信号转导》手册的 GABAB受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

其他說明

注意：不要冻存。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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K Yang et al.
Neuroscience, 193, 411-420 (2011-08-03)
Metabotropic GABA type B (GABA(B)) receptors are abundantly expressed in the rat spinal dorsal horn. Activation of GABA(B) receptors by exogenous agonists inhibits synaptic transmission, which is believed to underlie the GABA(B) receptor-mediated analgesia. However, little effort has been made
M Katherine Kelm et al.
Journal of neurophysiology, 100(6), 3417-3428 (2008-10-24)
Ethanol increases miniature inhibitory postsynaptic current frequency and decreases the paired-pulse ratio, which suggests that ethanol increases both spontaneous and evoked GABA release, respectively. We have shown previously that ethanol increases GABA release at the rat interneuron-Purkinje cell synapse and
Shuhei Kobuchi et al.
European journal of pharmacology, 623(1-3), 113-118 (2009-09-22)
Enhanced renal sympathetic nerve activity during ischemic period and the renal venous norepinephrine overflow after reperfusion play important roles in the development of ischemic acute kidney injury. We investigated the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter mainly in
A E Matukhno et al.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 62(3), 372-382 (2012-08-16)
By means of local microapplication of GABA, picrotoxin and CGP 52432, different roles of GABAA and GABAB receptors in the geneses of primary and secondary components of evoked potentials in the somatosensory barrel cortex of rats were shown. The authors
Chunguang Zhang et al.
Endocrinology, 150(5), 2388-2394 (2009-01-24)
Gamma-aminobutyric acid (GABA) is one of the most important neurotransmitters that regulate the excitability of GnRH neurons. Numerous studies have shown that GABA activates Cl(-) currents in GnRH neurons, and these effects are antagonized by GABA(A) receptor antagonists. The GABA(B)
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