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Merck
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Key Documents

C4461

Sigma-Aldrich

硫酸粘杆菌素 硫酸盐

≥19,000 IU/mg

别名:

多粘菌素E

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About This Item

CAS号:
1264-72-8
EC號碼:
215-034-3
MDL號碼:
MFCD00146495
分類程式碼代碼:
51102829
eCl@ss:
34050906
NACRES:
NA.85

形狀

powder

品質等級

200

比活性

≥19,000 IU/mg

抗生素活性譜

Gram-negative bacteria

作用方式

cell membrane | interferes

儲存溫度

2-8°C

InChI

1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1

InChI 密鑰

ZJIWRHLZXQPFAD-LRYSGCCDSA-N

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一般說明

化学结构：肽

應用

硫酸粘杆菌素被用于透化细菌细胞膜以及研究甘露糖抗性血凝和某些生物体(如鲍曼不动杆菌 A. baumannii )的抗生素耐药性。 它已被用于研究大鼠肾脏hephrotoxicity毒性 ，以及对铜绿假单胞菌的MIC值、时间杀灭动力学和抗生素后效应（PAE） 。

生化／生理作用

作用机制：与革兰氏阴性菌细胞质膜上的脂质结合并破坏细胞壁完整性。
抗菌谱： 革兰氏阴性菌。
作用机制：与革兰氏阴性菌细胞质膜上的脂质结合并破坏细胞壁完整性。
抗菌谱： 革兰氏阴性菌。硫酸粘杆菌素的肾重吸收被认为可能涉及到有机阳离子转运蛋白和肽转运蛋白，并且该过程对pH敏感 。

分析報告

易溶于水，几乎不溶于丙酮和乙醇（96％）

其他說明

保持容器密闭，置于干燥通风处。

相關產品

产品编号
说明
价格

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Peng Cui et al.
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Persisters are small populations of quiescent bacterial cells that survive exposure to bactericidal antibiotics and are responsible for many persistent infections and posttreatment relapses. However, little is known about how to effectively kill persister bacteria. In the work presented here
Deepesh Nagarajan et al.
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Drug resistance is a public health concern that threatens to undermine decades of medical progress. ESKAPE pathogens cause most nosocomial infections, and are frequently resistant to carbapenem antibiotics, usually leaving tigecycline and colistin as the last treatment options. However, increasing
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Journal of clinical microbiology, 57(3) (2018-12-21)
Acinetobacter baumannii is a prevalent nosocomial pathogen with a high incidence of multidrug resistance. Treatment of infections due to this organism with colistin, a last-resort antibiotic of the polymyxin class, can result in the emergence of colistin-resistant strains. Colistin resistance
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Antimicrobial agents and chemotherapy, 64(6) (2020-04-02)
Polymyxins are increasingly used as the critical last-resort therapeutic options for multidrug-resistant Gram-negative bacteria. Unfortunately, polymyxin resistance has increased gradually over the past few years. Although studies on polymyxin mechanisms are expanding, systemwide analyses of the underlying mechanism for polymyxin
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Antimicrobial agents and chemotherapy, 50(4), 1251-1256 (2006-03-30)
Acinetobacter baumannii has successfully developed resistance against all common antibiotics, including colistin (polymyxin E), the last universally active drug against this pathogen. The possible widespread distribution of colistin-resistant A. baumannii strains may create an alarming clinical situation. In a previous
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