所有图片(1)

文件

C2992

CFTR Inhibitor-172

Name: CFTR Inhibitor-172
Brand: SIGMA

≥98% (HPLC), powder, CFTR inhibitor

别名:

5-[（4-羧基苯基）亚甲基]-2-硫氧-3- [（3-三氟甲基）苯基-4-噻唑烷酮

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₈H₁₀F₃NO₃S₂

CAS号:

307510-92-5

分子量:

409.40

MDL號碼:

MFCD06411408

分類程式碼代碼:

12352200

PubChem物質ID:

24724436

NACRES:

NA.77

product name

CFTR（inh）-172, ≥98% (HPLC), powder

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

DMSO: ≥10 mg/mL
H₂O: insoluble

儲存溫度

2-8°C

SMILES 字串

OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F

InChI

1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+

InChI 密鑰

JIMHYXZZCWVCMI-RIYZIHGNSA-N

應用

CFTR（inh）-172用于特异性抑制囊性纤维化跨膜电导调节因子（CFTR）的活性。也可用作 CFTR抑制剂 Inh-172处理福司柯林（毛喉素）和IBMX。

生化／生理作用

CFTR (inh)-172 是囊性纤维化跨膜传导调节因子 (CFTR) 的抑制剂。K _i = 300 nM。CFTR (inh)-172 导致快速、可逆和非电压依赖性抑制；为动物止泻药。CTFR (inh)-172 可能是研究霍乱和其他分泌性腹泻囊性纤维化和肠液丢失动物模型的有用工具。CTFR (inh)-172 在结构上与已知的非特异性 CFTR 抑制剂 DPC，NPPB（货号N4779）和格列本脲。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

Tonghui Ma et al.

The Journal of clinical investigation, 110(11), 1651-1658 (2002-12-05)

Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is required for fluid secretion in the intestine and airways and, when

In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents.

N D Sonawane et al.

Journal of pharmaceutical sciences, 94(1), 134-143 (2005-03-12)

A small-molecule inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR), 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTR(inh)-172), reduces enterotoxin-induced intestinal fluid secretion in rodents. Here, we study CFTR(inh)-172 pharmacology and antidiarrheal efficacy in rodents using (14)C-labeled CFTR(inh)-172, liquid chromatography/mass spectrometry, and a closed intestinal

Electrophysiological evaluation of cystic fibrosis conductance transmembrane regulator (CFTR) expression in human monocytes

Ettorre M, et al.

Biochimica et biophysica acta. General subjects, 1840(10), 3088-3095 (2014)

Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis

Sorio C, et al.

Testing, 6(7), e22212-e22212 (2011)

An unexpected effect of TNF-alpha on F508del-CFTR maturation and function

Bitam S, et al.

F1000Research, 4 (2015)

查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

文件