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一般說明
化合物48/80,是一种N-甲基p-甲氧基苯乙基胺和甲醛缩合产物。
應用
48/80化合物可用来：
- 刺激血细胞释放组胺，从而通过ELISA和流式细胞仪测定
- 诱发肥大细胞脱粒
- 诱发小鼠过敏性活动、皮炎、瘙痒和炎症
生化／生理作用
化合物48/80是一种低血压药，促进组胺释放。C 48/80降低了 Styela plicata血细胞的吞噬能力。C 48/80 促进肥大细胞脱粒。它抑制钙调蛋白，磷脂酶C，内质网（ER）Ca2+磷酸酶和激活G蛋白。
準備報告
N-甲基-p-甲氧基苯乙基胺和甲醛缩合产物。
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKC alpha
Byrne RD, et al.
Cellular Signalling, 19(2), 321-329 (2007)
Meng-Li Wu et al.
Signal transduction and targeted therapy, 6(1), 428-428 (2021-12-19)
SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled hypercytokinemia is essential for treatments. Mast cells (MCs) are strategically located at the mucosa and beneficially or detrimentally regulate immune
Y Koibuchi et al.
European journal of pharmacology, 115(2-3), 163-170 (1985-09-24)
Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
Radhika Palkar et al.
The Journal of investigative dermatology, 138(6), 1391-1399 (2017-12-31)
Cooling or the application of mentholated liniments to the skin has been used to treat itch for centuries, yet remarkably little is known about how counter-stimuli such as these induce itch relief. Indeed, there is no clear consensus in the
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)
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