推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
human, mouse, rat
技術
immunocytochemistry: suitable
western blot: 1:200 using rat heart membranes
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CACNA1C(775)
mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)
特異性
可识别小鼠Cav1.2，大鼠Cav1.2的剪接变体P22002-4和P22002-5，以及兔Cav1.2的剪接变体P15381-4。
免疫原
对应于人Cav1.2残基2-15的多肽（外显子1B）。该序列的14/15个残基与小鼠和大鼠体内的相同。
生化／生理作用
L型电压依赖性钙通道α1C亚基（Cav1.2）是人类CACNA1C基因编码的蛋白质，属于电压门控钙通道家族。它是细胞表面膜电位变化到可引发不同生理事件的局部细胞内钙瞬变的关键转导蛋白。CACNA1C是L型电压依赖性钙通道的亚基。它定位于染色体12p13.3，并被认为是精神分裂症的易感基因。CACNA1C在人TH2细胞中选择性表达，阻断TH2细胞Cav1.2通道激活可能是治疗人类受试者过敏性疾病的新策略。其活性增加与痴呆和阿尔茨海默病（AD）的发病机制有关。′
標靶描述
钙通道CaV1.2（CACNA1C）编码电压依赖性钙通道的α-1亚基。钙离子通道在膜极化时介导钙离子流入细胞。
外觀
由含有1% BSA和0.05% 叠氮化钠的pH 7.4的磷酸盐缓冲液冻干。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Fanfan Zheng et al.
Schizophrenia research, 152(1), 105-110 (2013-12-21)
CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether
Monika A Davare et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(26), 16018-16023 (2003-12-11)
An increase in Ca2+ influx through L-type Ca2+ channels is thought to contribute to neuronal dysfunctions that underlie senile symptoms and Alzheimer's disease. The molecular basis of the age-dependent up-regulation in neuronal L-type Ca2+ channel activity is largely unknown. We
Man Xu et al.
The Journal of biological chemistry, 278(42), 40837-40841 (2003-08-06)
Voltage-gated calcium (Ca2+) channels play a key role in the control of heart contraction and are essential for normal heart development. The Cav1.2 L-type calcium channel is the predominant isoform in cardiomyocytes and is essential for excitation-contraction coupling. Although the
Virginie Robert et al.
The Journal of allergy and clinical immunology, 133(4), 1175-1183 (2013-12-25)
In addition to calcium release-activated calcium channel/ORAI calcium channels, the role of voltage-gated calcium (Cav1) channels in T-cell calcium signaling is emerging. Cav1 channels are formed by α1 (CaV1.1 to CaV1.4) and auxiliary subunits. We previously demonstrated that mouse TH2
Sven Moosmang et al.
The EMBO journal, 22(22), 6027-6034 (2003-11-12)
Blood pressure is regulated by a number of key molecules involving G-protein-coupled receptors, ion channels and monomeric small G-proteins. The relative contribution of these different signaling pathways to blood pressure regulation remains to be determined. Tamoxifen-induced, smooth muscle-specific inactivation of
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