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B2292

Sigma-Aldrich

O6-苄基鸟嘌呤

≥98% (TLC), solid, O⁶-alkylguanine DNA alkyltransferase inhiitor

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About This Item

经验公式（希尔记法）:
C12H11N5O
CAS号:
19916-73-5
分子量:
241.25
MDL號碼:
MFCD00269931
分類程式碼代碼:
12352200
PubChem物質ID:
24278259
NACRES:
NA.77

product name

O6-苄基鸟嘌呤, ≥98% (TLC), solid

品質等級

200

化驗

≥98% (TLC)

形狀

solid

溶解度

methanol: 20 mg/mL

儲存溫度

room temp

SMILES 字串

Nc1nc(OCc2ccccc2)c3nc[nH]c3n1

InChI

1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)

InChI 密鑰

KRWMERLEINMZFT-UHFFFAOYSA-N

基因資訊

human ... MGMT(4255)

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應用

使用O6-苄基鸟嘌呤：
  • 用作胶质母细胞瘤干细胞中甲基鸟嘌呤甲基转移酶(MGMT)抑制剂
  • 在N-乙基-N-亚硝基脲(ENU)疗法之前用作胚胎干细胞中的O6-烷基鸟嘌呤-烷基转移酶(AGT)的酶抑制剂
  • 在HL-60人早幼粒白血病生长抑制试验中AGT的抑制剂

生化／生理作用

O6-苄基鸟嘌呤(O6BG)可通过苄基转移阻断活性部位来抑制甲基鸟嘌呤甲基转移酶(MGMT)。使用O6BG与双氯乙基亚硝基脲(BCNU)或卡莫司汀治疗包括淋巴瘤、黑色素瘤和肉瘤等实体肿瘤是有效的。
O(6)-苄基鸟嘌呤是一种抗肿瘤剂，它通过与DNA修复酶O(6)-烷基鸟嘌呤DNA烷基转移酶（AGT）结合，抑制AGT介导的DNA修复。它被广泛用于各种DNA修复机制研究，并且可加强其他破坏DNA的化疗药物的作用。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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