A8800

阿普唑仑

• 别名: 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
• 经验公式（希尔记法）: C₁₇H₁₃ClN₄
• CAS号: 28981-97-7
• 分子量: 308.76
• EC號碼: 249-349-2
• MDL號碼: MFCD00078881
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24891366
• NACRES: NA.77

属性

• 形狀: powder
• 品質等級: 200
• 藥物控制: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 溶解度: H₂O: insoluble; methanol: soluble
• 應用: forensics and toxicology; pharmaceutical (small molecule); veterinary
• 起源: Johnson & Johnson
• SMILES 字串: Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12
• InChI: 1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
• InChI 密鑰: VREFGVBLTWBCJP-UHFFFAOYSA-N
• 基因資訊: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

说明

一般說明

Alprazolam is a triazole-containing benzodiazepine that is related to diazepam and other 1,4-benxodiazepines. Like other benzodiazepines, Alprazolam is a GABAergic agonist that modulates GABA_A receptors. GABA_A receptors in the central nervous system are ligand-gated ion channels that are bound by the stimulatory neurotransmitter GABA; binding of this ligand allows ion movement through the channel and results in neurotransmission inhibition.

生化／生理作用

Alprazolam binds the GABA_A receptor at the benzodiazepine site, which is different than the ligand-binding site at which GABA binds. Alprazolam has been shown to be an anxiolytic (anti-anxiety agent) as well as having anticonvulsant, muscle relaxant and antidepressant activity.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves