推荐产品
product name
Amastatin hydrochloride hydrate, ≥97% (HPLC)
生物源
synthetic (organic)
品質等級
化驗
≥97% (HPLC)
形狀
powder
mp
202-205 °C
溶解度
methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)
抗生素活性譜
neoplastics
作用方式
enzyme | inhibits
儲存溫度
−20°C
SMILES 字串
Cl[H].[H]O[H].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
InChI
1S/C21H38N4O8.ClH.H2O/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H;1H2/t12-,13+,15+,16+,17+;;/m1../s1
InChI 密鑰
WBYDQJQQTMJMQH-AFROIDPFSA-N
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一般說明
Chemical structure: peptide
生化/生理作用
It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.
Effective concentration: 1-10 μM.
Effective concentration: 1-10 μM.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Proteolytic Enzymes: A Practical Approach, 247-247 (1989)
Handbook of Enzyme Inhibitors, 2nd Ed., 547-547 (1993)
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(3), e21419-e21419 (2021-02-11)
In the early phase of the Coronavirus disease 2019 (COVID-19) pandemic, it was postulated that the renin-angiotensin-system inhibitors (RASi) increase the infection risk. This was primarily based on numerous reports, which stated that the RASi could increase the organ Angiotensin-converting
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